Persistence of the Entire Epstein-Barr Virus Genome Integrated into Human Lymphocyte DNA
- 14 December 1984
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 226 (4680) , 1322-1325
- https://doi.org/10.1126/science.6095452
Abstract
The entire Epstein-Barr virus genome is integrated into Burkitt tumor cell DNA at the terminal direct repeat sequence of the virus. There is no homology between the GC-rich (G, guanine; C, cytosine) terminal repeat and the AT-rich (A, adenine; T, thymine) cell sequences with which it has recombined. More than 15 kilobases of cell DNA have been deleted and 236 base pairs are duplicated at one virus-cell junction site.Keywords
This publication has 19 references indexed in Scilit:
- Mapping of the Human Blym -1 Transforming Gene Activated in Burkitt Lymphomas to Chromosome 1Science, 1984
- A specific viral DNA sequence is stably integrated in herpesvirus oncogenically transformed cellsCell, 1983
- Structure and role of the herpes simplex virus DNA termini in inversion, circularization and generation of virion DNACell, 1982
- The pUC plasmids, an M13mp7-derived system for insertion mutagenesis and sequencing with synthetic universal primersGene, 1982
- DNA of Epstein-Barr virus VIII: B95-8, the previous prototype, is an unusual deletion derivativeCell, 1980
- Cloning in single-stranded bacteriophage as an aid to rapid DNA sequencingJournal of Molecular Biology, 1980
- The isolation and characterization of linked δ- and β-globin genes from a cloned library of human DNACell, 1978
- Charon Phages: Safer Derivatives of Bacteriophage Lambda for DNA CloningScience, 1977
- Covalently closed circular duplex DNA of Epstein-Barr virus in a human lymphoid cell lineJournal of Molecular Biology, 1976
- Relationship between the sensitivity of EBV‐carrying lymphoblastoid lines to superinfection and the inducibility of the resident viral genomeInternational Journal of Cancer, 1973