Hämolytische Krise bei Mangel an Glukose-6-Phosphatdehydrogenase und Bleiintoxikation

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Abstract
The observation of an acute hemolytic crisis associated with a moderate degree of lead poisoning in a patient with glucose-6-phosphate dehydrogenase (G-6-PD) deficiency provides the occasion for a comparison of these pathogenetic factors for anemia. The hematological changes brought about by Pb poisoning[long dash]hemolysis, disturbance of globin and heme synthesis[long dash]and by G-6-PD deficiency are described. It is assumed that lead poisoning does not act as an oxidant on the erythrocyte metabolism as is the case in typical favism, but by the direct blocking of essential sulfhydryl groups. The process of cell destruction follows the same course as with drug-induced hemolysis. The biochemical basis of the accelerated destruction of the red cells is discussed.

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