Studies of the stability and toxicity of zinc polyacrylate (polycarboxylate) cements (PAZ)

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Abstract
Zinc polycarboxylate cement (PAZ) was shown to actively bond to 45Ca in vitro, with maximum uptake occurring at a Ca+2 concentration of 0.2 mg/ml. When the resultant PAZ‐45Ca complex was subsequently incubated in the presence of high levels of unlabeled Ca+2, there was an exchange between the 45Ca bond to the cement and the Ca+2 in solution. When PAZ prepared using 65Zn was incubated with high levels of Ca+2, there was no exchange between the Ca and the 65Zn. 14C‐PA failed to be taken up by L‐cells in tissue culture, during 16 division cycles. Using radioactive PAZ prepared from 14C‐PA, the PA moiety of the cement was shown to be extremely insoluble and stable in vivo.

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