Clearance of Hepatitis C Virus after Newly Acquired Infection in Injection Drug Users
Open Access
- 1 October 2004
- journal article
- Published by Oxford University Press (OUP) in The Journal of Infectious Diseases
- Vol. 190 (7) , 1270-1274
- https://doi.org/10.1086/423943
Abstract
A retrospective cohort of injection drug users with newly acquired hepatitis C virus (HCV) infection was established to examine viral clearance. Newly acquired HCV infection was defined by anti-HCV antibody seroconversion within a 2-year interval. Stored serum samples were tested for HCV RNA, with viral clearance defined as ⩾2 consecutive negative HCV RNA test results after infection. Ninety-nine cases of HCV infection were identified; 57 had ⩾2 HCV RNA test results after infection. Viral clearance occurred in 24 (42%) cases, with Kaplan-Meier estimated probabilities of 23%, 38%, and 40% at 6, 12, and 24 months, respectively.Keywords
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