DNA activates human immune cells through a CpG sequence‐dependent manner
Open Access
- 1 August 1999
- journal article
- research article
- Published by Wiley in Immunology
- Vol. 97 (4) , 699-705
- https://doi.org/10.1046/j.1365-2567.1999.00811.x
Abstract
While bacterial DNA and cytosine–guanosine-dinucleotide-containing oligonucleotides (CpG ODN) are well described activators of murine immune cells, their effect on human cells is inconclusive. We inv...Keywords
This publication has 36 references indexed in Scilit:
- CpG‐containing synthetic oligonucleotides promote B and cytotoxic T cell responses to protein antigen: A new class of vaccine adjuvantsEuropean Journal of Immunology, 1997
- Bacterial DNA-Induced NK Cell IFN-γ Production Is Dependent on Macrophage Secretion of IL-12Clinical Immunology and Immunopathology, 1997
- Bacterial DNA causes septic shockNature, 1997
- Immunostimulatory DNA Sequences Necessary for Effective Intradermal Gene ImmunizationScience, 1996
- B-Cell Proliferation and Differentiation in Common Variable Immunodeficiency Patients Produced by an Antisense Oligomer to therevGene of HIV-1Clinical Immunology and Immunopathology, 1996
- Bacterial DNA Induces Murine Interferon-γ Production by Stimulation of Interleukin-12 and Tumor Necrosis Factor-αCellular Immunology, 1996
- CpG motifs in bacterial DNA trigger direct B-cell activationNature, 1995
- Synthetic Oligonucleotides with Certain Palindromes Stimulate Interferon Production of Human Peripheral Blood Lymphocytes in vitroJapanese Journal of Cancer Research, 1994
- In vitro Augmentation of Natural Killer Cell Activity and Production of Interferon‐α/β and ‐γ with Deoxyribonucleic Acid Fraction from Mycobacterium bovis BCGJapanese Journal of Cancer Research, 1988
- CpG-rich islands and the function of DNA methylationNature, 1986