Relationship between Serum Lipid Components in Hyperlipemia

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Abstract
The association between lipid components in blood serum in normo- and hyperlipemia was investigated in the present study. There was a close correlation between total cholesterol and sphingomyelin, expressed by the formula: (cholesterol) = a+b (sphingo-myelin), with a correlation coefficient of 0.92 for normotriglyceridemia and 0.90 for hypertriglyceridemia. A difference in the slope of the correlation curve (b) between these two groups seems to be due to the presence of cholesteryl ester as a load instead of the original constituent of the lipoprotein. There was an association between lecithin and triglyceride shown by the formula, (triglyceride) = a-(lecithin excess)k, where lecithin excess is defined as: (lecithin+lyso-lecithin−2 × sphingomyelin). The fatty acid composition of lecithin and triglycerides in blood serum was similar to the fatty acid composition of the corresponding lipid fractions in the liver. In the liver and the xanthoma of the skin in cases of hyperlipemia, there was an increase in acidic glycerophospholipid, lysobisphosphatidic acid or bis-(monoacyl-glyceryl)phosphate.

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