Studies on Benzothiazoline Derivatives. II. Syntheses of Benzothiazoline Derivatives possessing Substituent Groups at 2- and 3-Positions
Open Access
- 1 January 1978
- journal article
- research article
- Published by Pharmaceutical Society of Japan in YAKUGAKU ZASSHI
- Vol. 98 (8) , 1019-1027
- https://doi.org/10.1248/yakushi1947.98.8_1019
Abstract
A general method was established for useful synthesis of benzothiazoline derivatives possessing various functional groups. Reduction of benzothiazolium salts with sodium borohydride in pyridine and reaction of these salts with Grignard agents were examined and many 2,3-disubstituted and 2,2,3-trisubstituted benzothiazoline derivatives were synthesized. Among the benzothiazoline derivatives so obtained, some analgesic and antiinflammatory activities in rats were found using 3-methyl-2-phenyl- and 2,3-dimethyl-2-phenyl-5-benzothiazolineacetic acids.Keywords
This publication has 1 reference indexed in Scilit:
- Carrageenin-Induced Edema in Hind Paw of the Rat as an Assay for Antiinflammatory DrugsExperimental Biology and Medicine, 1962