Different effects of furosemide on urinary excretion of prostaglandin E2and F2αin rabbits

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Abstract
The effect of a constant infusion of furosemide (130 μg/min i.v. for 60 min, n = 8) was studied on urinary excretion of water, electrolytes and immunoreactive prostaglandin E2(iPGE2) and iPGF2αin chloralose‐urethane anesthetized rabbits. During the furosemide infusion sodium and water excretion increased tenfold and the excretion of potassium and iPGE2two to three times. The excretion of iPGF2α(0.06 ± 0.03 μg/min/100 g kidney weight) was not significantly changed during the furosemide infusion but increased markedly after the infusion and reached a maximum (1.0 ± 0.6 μg/min/100 g) 30 to 45 min later, while the small increase in iPGE2excretion at this time could be attributed to cross‐reaction with PGF2αThe results indicate that PGE2might possibly be involved directly in the action of furosemide, while PGF2αmight participate in sodium and water conserving mechanisms in the rabbit kidney, activated by the drug induced diuresis.