The effect of pimozide on the establishment of conditioned reinforcement

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Abstract
The effect of pimozide on conditioned reinforcement was determined by comparing rate of lever pressing for a tone in groups previously treated with or without the drug when the tone was paired with food. Eight groups of six to eight rats each received three phases of training in a two-lever box. The pre-exposure phase measured the operant rate of pressing the two levers, one of which produced a 3 s tone. In the conditioning phase, with the levers absent, the tone was paired with food over four sessions. The test phase again measured the rate of pressing the two levers. In an undrugged experimental group (i.e., Paradigm group), the number of presses on the tone lever significantly increased from the pre-exposure to the test phase, thereby confirming that the procedure could establish conditioned reinforcement. A control group receiving tones and pellets randomly during the conditioning phase also showed conditioned reinforcement but a group receiving negatively correlated tones and pellets did not. Groups receiving the dopamine-receptor blocker pimozide (1.0 mg/kg) prior to each conditioning session failed to show conditioned reinforcement in the test session. Control groups ruled out state dependent learning and drug-induced performance impairments as explanations of this pimozide-related effect. These data may indicate a possible role for dopamine neurons in mediating the control of behavior by certain positive reinforcing stimuli.