Enzymatic Removal of Bilirubin From Blood: A Potential Treatment for Neonatal Jaundice
- 1 November 1985
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 230 (4725) , 543-545
- https://doi.org/10.1126/science.4048947
Abstract
Current treatments for severe jaundice can result in major complications. Neonatal jaundice is caused by excessive accumulation of bilirubin in the blood. A small blood filter containing immobilized bilirubin oxidase was developed to reduce serum bilirubin concentrations. When human or rat blood was passed through the enzyme filter, more than 90 percent of the bilirubin was degraded in a single pass. This procedure may have important applications in the clinical treatment of neonatal jaundice.This publication has 15 references indexed in Scilit:
- Mechanisms and Significance of Fasting and Dietary HyperbilirubinemiaSeminars in Liver Disease, 1983
- A new approach (cyano-transfer) for cyanogen bromide activation of Sepharose at neutral pH, which yields activated resins, free of interfering nitrogen derivativesBiochemical and Biophysical Research Communications, 1982
- An Enzymatic System for Removing Heparin in Extracorporeal TherapyScience, 1982
- Quantitative correspondence between the in vivo and in vitro activity of teratogenic agents.Proceedings of the National Academy of Sciences, 1982
- Isolation and identification of a microorganism producing bilirubin oxidase.Agricultural and Biological Chemistry, 1982
- Phenylalanine Depletion for the Management of Phenylketonuria: Use of Enzyme Reactors with Immobilized EnzymesScience, 1978
- Perfusion trails with a collagen‐immobilized enzyme in an extracorporeal reactor: Activity, stability, and biocompatibilityJournal of Biomedical Materials Research, 1977
- Removing Substances from Blood by Affinity ChromatographyJournal of Clinical Investigation, 1974
- Mechanism of bilirubin toxicity on tissue culture cells: Factors that affect toxicity, reversibility by albumin, and comparison with other respiratory poisons and surfactantsBiochemical Medicine, 1971
- Albumin standards and the measurement of serum albumin with bromcresol greenClinica Chimica Acta; International Journal of Clinical Chemistry, 1971