Growth Retardation in Offspring of Female Rats Treated with Morphine Prior to Conception
- 11 February 1972
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 175 (4022) , 654-656
- https://doi.org/10.1126/science.175.4022.654
Abstract
Treatment of female rats with morphine sulfate for 5 ½ or 10 days, prior to drug withdrawal for 5 days and subsequent mating, results in retarded growth of offspring. The effect is not present at birth but appears at 3 to 4 weeks of age. It occurs even though offspring are not exposed to morphine in utero or postnatally. It is not eliminated by cross-fostering and is apparently of prenatal origin.Keywords
This publication has 14 references indexed in Scilit:
- Effects on offspring behavior of mothers' early chronic drug experiencePsychopharmacology, 1969
- Morphine-Induced Fetal Malformations IJournal of Pharmaceutical Sciences, 1968
- Infantile stimulation and adult exploratory behaviour in the rat: Effects of handling upon visual variation-seekingAnimal Behaviour, 1967
- Induction of morphine tolerance by material extracted from brain of tolerant animalsInternational Journal of Neuropharmacology, 1966
- Effect of tranquilizing drugs on postnatal behaviorExperimental Neurology, 1966
- Drugs as Teratogens in Animals and ManAnnual Review of Pharmacology, 1965
- Effect of Injection of Tranquillizing Drugs During Pregnancy on OffspringNature, 1965
- Potentiation of an effect of morphine in the rat by sera from morphine-tolerant and abstinent dogs and monkeysPsychopharmacology, 1963
- Learning Deficits of Offspring after Administration of Tranquillizing Drugs to the MothersNature, 1963
- Postnatal behavioral effects of tranquilizers administered to the gravid ratExperimental Neurology, 1962