A Method of Correcting for Linear Drift in Computed Tomography Brain Scans

Abstract
Linear drift of X-ray attenuation coefficients must be corrected if quantitative comparisons are to be made between computed tomography (CT) brain scans of the same individual performed at different times. Such a correction is accomplished by comparing the low (CSF) end of the attenuation coefficient frequency histograms using a percentile-percentile plot. A drift correction permits serial quantitative assessments of the progression or regression of white matter hypodensity, such as occurs in patients with drug induced leukoencephalopathy.

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