Structure of nucleosome core particles of chromatin
- 1 September 1977
- journal article
- research article
- Published by Springer Nature in Nature
- Vol. 269 (5623) , 29-36
- https://doi.org/10.1038/269029a0
Abstract
Crystals have been obtained of nucleosome cores and analysed by X-ray diffraction and electron microscopy. The core is a flat particle of dimensions about 110 × 110 × 57 Å, somewhat wedge shaped, and strongly divided into two ‘layers’, consistent with the DNA being wound into about 1¾ turns of a fiat superhelix of a pitch about 28 Å. The organisation of the DNA can be correlated with the results of enzyme digestion studies. A change in the screw of the DNA double helix on nucleosome formation can be deduced.This publication has 36 references indexed in Scilit:
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