Heat production rate in polymorphonuclear granulocytes from patients with acute myelogenous leukaemia and healthy individuals

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Abstract
Heat production rate in polymorphonuclear granulocytes (PMN) from 18 AML [acute myelogenous leukemia] patients and 21 healthy individuals was measured using microcalorimetry. An incrased PMN heat production rate was found in most AML patients at diagnosis and during the first 6 mo. of remission. In 7/7 patients showing values above the normal mean level the heat production rate decreased during sequential analysis. The increased PMN heat production rate is serum dependent and leukemic sera induced increased calorimetric values also in PMN from healthy donors. This effect was not due to heat labile complement factors.