C-PEPTIDE ANTIBODIES INDUCED BY BOVINE INSULIN THERAPY

  • 1 January 1982
    • journal article
    • research article
    • Vol. 50  (1) , 171-177
Abstract
Antibodies reactive with the C-peptide portion of proinsulin can be detected in the sera of patients on conventional bovine insulin regimes which include the soluble form. Direct and competitive binding studies demonstrate that C-peptide antibodies show species specificity but do not recognize free homologous C-peptide. This is likely to be due to conformational change following cleavage of C-peptide from the proinsulin molecule. Examination of sera from a large group of patients established on a standard insulin regime shows that C-peptide and insulin antibody levels do not correlate with each other, and are likely to show different patterns of genetic control.