Abstract
A case [human] of chronic graft vs. host disease had scleroderma-like skin changes. Clinical progression was from poikiloderma to scleroderma, and histopathological changes and results of direct immunofluorescence were noted. It is probable that both cell-mediated (T[thymus derived]-cell) and humoral (B[bone marrow derived]-cell] mechanisms contribute to the pathogenesis of the graft vs. host reaction.

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