Effects of prostaglandins E1,E2,F2.ALPHA. and I2 on adrenergic transmission in guinea pig pulmonary arteries.

1 January 1988

journal article
research article
Published by Elsevier in The Japanese Journal of Pharmacology

Vol. 48 (1) , 153-156
https://doi.org/10.1254/jjp.48.153

Abstract

Effects of some prostaglandins (PGs) on adrenergic transmission were studied in guinea pig pulmonary arteries preloaded with 3H-norepinephrine. PGE1 and PGE2 at 0.1 to 100 nM concentration-dependently inhibited 3H-release and contracton evoked at 5 Hz. This inhibition was antagonized by diphloretin phosphate. PGF2.alpha. at 1 to 100 nM had no effect on evoked 3H-release and contraction. PGI2 at 1 to 100 nM also failed to modify evoked 3H-release, but markedly and concentration-dependently decreased evoked contraction. There exist presynaptic inhibitory PGE1 and PGE2 receptive sites on adrenergic neurons innervating guinea pig pulmonary arteries, whereas PGF2.alpha. and PGI2 produced no effect on the adrenergic neurons.

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