Enhanced potency of truncated insulin-like growth factor-I (des(1–3)IGF-I) relative to IGF-I in lit/lit mice
- 1 December 1990
- journal article
- research article
- Published by Bioscientifica in Journal of Endocrinology
- Vol. 127 (3) , 401-405
- https://doi.org/10.1677/joe.0.1270401
Abstract
The relative potencies of insulin-like growth factor (IGF-I) and the N-terminal truncated derivative, des(1–3)IGF-I, have been compared in lit/lit mice. Injection of 30 μg IGF-I, 30 μg des(1–3)IGF-I or 3 μg des(1–3)IGF-I daily for 3 weeks increased total length and nose-rump length of the animals substantially more than in controls or animals treated with 3 μg IGF-I daily. Body weight changes were not statistically significant. The lower dose of des(1–3)IGF-I, but not that of IGF-I, led to increases in kidney and heart weights relative to controls, while the higher dose of either IGF-I or des(1–3)IGF-I also increased the weights of liver, lungs and stomach. These results indicate that the higher potency of des(1–3)IGF-I demonstrated in cultured cells also applies in vivo to at least one strain of GH-deficient animals. Journal of Endocrinology (1990) 127, 401–405Keywords
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