The influence of acetamide on citrate accumulation after fluoroacetate poisoning

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Abstract
The protective effect of acetamide in fluoroacetate poisoning is accompanied in heart and kidney by citrate concentrations that are significantly lower than those found without acetamide. Citrate accumulation in brain is not altered by acetamide. Monoacetin also produces a decreased citrate level in fluoroacetate -treated animals. Both acetamide and monoacetin, however, produce increased citrate concentrations in brain, heart and kidney, when given without fluoroacetate. Citrate concentrations were proportional to the dose of fluoroacetate and to the period of time after administration of fluoroacetate. Acetamide does not counteract the effect of fluoroacetate poisoning once this has led to a toxic concentration of fluorocitrate in the cells. It does, however, counteract the formation of fluorocitrate and gives protection to white rats when injected before and even up to 8 minutes after administration of fluoroacetate.