A Case of Centrolobular Toxic Necrosis of the Liver Due to Aromatic Retinoid – Tigason (Ro 10-9359)

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Abstract
A woman aged 54 years developed toxic necrosis of liver cells during treatment with aromatic retinoid (Ro 10–9359) for erythrodermia ichthyosiformis non-bullosa. Her skin was almost normalized when liver function tests and liver biopsy disclosed severe damage. The treatment was stopped, but 4 months later ALAT and ASAT were still elevated.

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