LOSS OF ENDOTOXIN LIBERATION IN NEISSERIA MENINGITIDIS

Abstract
Four strains of N. meningitidis were studied during serial passage. Upon subcultivation, 2 of them lost the ability to liberate endotoxin. Ultrastructurally, the 2 parent endotoxin liberating strains exhibited quantively more free cell wall membranes and blebs in the medium than their non-liberating variants. The endotoxin-releasing original strains exhibited higher sulfonamide resistance than their variants and had markedly more stickly cells, which showed pronounced adherence to the surfaces of plastic and heated blood agar.

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