Cytotoxic Polyacetylenes from the Marine Sponge Petrosia sp.
- 13 February 1999
- journal article
- review article
- Published by American Chemical Society (ACS) in Journal of Natural Products
- Vol. 62 (4) , 554-559
- https://doi.org/10.1021/np9803427
Abstract
Three C46 (1−3) and three C30 (4−6) polyacetylenic alcohols with cytotoxic activity against a small panel of human solid-tumor cell lines have been isolated from the marine sponge Petrosia sp. Although compound 1 was identified as the stereoisomer of petrocortyne A, the structures of compounds 2−5 have not been previously reported and were established by spectral methods. Compound 6 was identified as the known compound petrosiacetylene D. The stereochemistry of compounds 1−5 was determined by the modified Mosher's method.Keywords
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