Longitudinal Study of Calcium Metabolism in Male Puberty

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Abstract
Height velocity, bone mineral content (BMC), serum concentrations of alkaline phosphatase (AP), testosterone, dehydroepiandrosterone (DHEA) and androstenedione (A-dione) were determined as a part of a longitudinal study of Ca metabolism in normal male puberty. The time of maximal increase (Tm) in concentrations was calculated for 20 boys from a curve-fitting analysis program. Highly significant correlations were found between Tm testosterone and Tm BMC (r = 0.73, P < 0.001); Tm AP and Tm BMC (r = 0.68, P < 0.001). The mean difference in time between Tm testosterone and Tm BMC was 4.7 mo. and between Tm AP and Tm testosterone 0.7 mo. A very close relationship between testosterone, osteoblastic activity and mineralization in normal male puberty is indicated; the adrenal androgens do not seen to have a major influence on the mineralization at the male puberty growth spurt phase.