Clinical Evaluation of Antihypertensive Drugs

Publisher Website
Google Scholar
Abstract
Evaluation in patients of the effectiveness of antihypertensive drugs has become a large undertaking, for which, the bases of the evaluations are not well defined. Our procedure consists in using averages of resting blood pressure as representative data and correlating these with estimates of the severity of hypertensive disease (distributed under the renal, cardiac and cerebral panels), during control periods, in the hospital of one or more week''s duration. The study is carried on primarily in patients with severe hypertensive disease, in whom the possible effects of treatment can be more easily evaluated than in patients with less severe disease. Placebos are used, usually during the control period; the double-blind test is not considered useful for this purpose. Selected patients are urged to take their own blood pressure at home after discharge from hospital; the averages of these measurements extend the period of therapeutic trial over months and years. The use of single medications composed of mixtures of drugs ("cocktails") is deplored.

This publication has 2 references indexed in Scilit: