NEW N-NITROSO COMPOUND, N-3-METHYLBUTYL-N-1-METHYLACETONYLNITROSAMINE, IN CORN-BREAD INOCULATED WITH FUNGI

  • 1 January 1979
    • journal article
    • research article
    • Vol. 22  (5) , 601-+
Abstract
A new N-nitroso compound [and possible carcinogen], N-1-methylacetonyl-N-3-methylbutylnitrosamine (MAMBNA), is found in cornbread inoculated with common fungi such as Fusarium moniliforme, Geotrichum candidum, Aspergillus terreus or A. flavipes encountered in food of Lin Xian County, Henan Province [China]. The preliminary identification of this compound with TLC [thin layer chromatography] was confirmed by GC-MS [gas chromatography and mass spectrometry] analysis. MAMBNA was synthesized and the chemical analysis shows that it is identical with the MAMBNA isolated from the cornbread extract. In addition to MAMBNA, dimethylnitrosamine, diethylnitrosamine and methylbenzylnitrosamine are also formed in the fungus-inoculated cornbread after an 8 day incubation and an addition of a small amount of sodium nitrite. The presence of precursor compounds for the formation of nitrosamines in the moldy maize flour and their significance in respect to the etiology of esophageal cancer in high-risk areas are discussed.

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