Dietary Effects on Development of Pancreatic Xanthine Dehydrogenase in the Newly Hatched Chick
- 1 October 1972
- journal article
- research article
- Published by Elsevier in Journal of Nutrition
- Vol. 102 (10) , 1347-1355
- https://doi.org/10.1093/jn/102.10.1347
Abstract
Chick pancreatic xanthine dehydrogenase (PXDH) is synthesized in response to feeding after hatching; its specific activity increases more than 200-fold within a week. Unfed chicks develop little PXDH activity. To determine which dietary ingredients were critical in regulating this developmental pattern, chicks were fed synthetic diets in which each ingredient was varied independently. Except for those containing unsaturated fatty acids or excess arginine, each diet supported PXDH activity and weight gain to the same extent, indicating that growth and PXDH synthesis are regulated together. No dietary ingredient was found which would enhance PXDH activity above the level predicted by weight gain. Three ingredients suppressed PXDH activity: linoleic and linolenic acids and arginine. These are found in high concentrations in egg yolk. At hatching, the chick's nutritional intake normally shifts from yolk to a predominantly grain diet containing lower concentrations of these acids; this change is probably important in the initiation of PXDH accumulation.Keywords
This publication has 8 references indexed in Scilit:
- Synthesis of xanthine dehydrogenase in liver and pancreas of developing chicksDevelopmental Biology, 1971
- Suppression of chick pancreatic xanthine dehydrogenase by unsaturated fatty acidsDevelopmental Biology, 1971
- Synthesis and degradation of xanthine dehydrogenase during chick liver developmentDevelopmental Biology, 1969
- Control of xanthine dehydrogenase in the chick pancreasDevelopmental Biology, 1967
- Developmental changes and control of xanthine dehydrogenases in developing chicksDevelopmental Biology, 1967
- Interrelationship of Plasma Amino Acid Levels and Weight Gain in the Chick as Influenced by Suboptimal and Superoptimal Dietary Concentrations of Single Amino AcidsJournal of Nutrition, 1965
- Evidence of a Specific Effect of Cystine in the Prevention of Nutritional Muscular Dystrophy in Vitamin E-Deficient ChicksJournal of Nutrition, 1962
- CHOLINE IN THE NUTRITION OF CHICKSJournal of Biological Chemistry, 1941