The protein phosphatase 2C (PP2C) superfamily: Detection of bacterial homologues
Open Access
- 1 July 1996
- journal article
- for the-record
- Published by Wiley in Protein Science
- Vol. 5 (7) , 1421-1425
- https://doi.org/10.1002/pro.5560050720
Abstract
A thorough sequence analysis of the various members of the eukaryotic protein serine/threonine phosphatase 2C (PP2C) family revealed the conservation of 11 motifs. These motifs could be identified in numerous other sequences, including fungal adenylate cyclases that are predicted to contain a functionally active PP2C domain, and a family of prokaryotic serine/threonine phosphatases including SpoIIE. Phylogenetic analysis of all the proteins indicates a widespread sequence family for which a considerable number of isoenzymes can be inferred.Keywords
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