Synthesis of N-acylacetoacetamide using 2,2,6-trimethyl-1,3-dioxin-4-one.
- 1 January 1982
- journal article
- Published by Pharmaceutical Society of Japan in CHEMICAL & PHARMACEUTICAL BULLETIN
- Vol. 30 (4) , 1315-1321
- https://doi.org/10.1248/cpb.30.1315
Abstract
Diketene-acetone adduct (2, 2, 6-trimethyl-1, 3-dioxin-4-one) 1 reacts with amide NH to give the corresponding N-acetoacetates 2. Formamide and basic amides such as picolinamide, on treatment with the adduct, are transformed to the N-acyl-2, 6-dimethyl-4-oxo-4H-pyran-3-carboxamide (4a and 4p) together with the corresponding N-acetoacetates.Keywords
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