Presentation of Peptide Antigens as Albumin Conjugates for Use in Detection of Serum Antibodies by Enzyme-Linked Immunosorbent Assay
- 1 January 1996
- journal article
- Published by American Chemical Society (ACS) in Bioconjugate Chemistry
- Vol. 7 (3) , 338-342
- https://doi.org/10.1021/bc960018s
Abstract
The use of linear peptides as antigens for detection of serum antibodies has been studied using a sequence of the Borrelia burgdorferi protein, flagellin, and Lyme disease sera as a model. It was found that a novel presentation of the peptide as a hapten on the carrier protein, bovine serum albumin, in the enzyme-linked immunosorbent assay format can be successfully applied to distinguish between Lyme disease and control sera.Keywords
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