CORRELATION BETWEEN LOCAL OXYGEN-TENSION IN MUSCLE-TISSUE AND SURVIVAL TIME IN TOURNIQUET SHOCK

  • 1 January 1977
    • journal article
    • research article
    • Vol. 4  (1) , 35-40
Abstract
Tourniquet shock was induced in rabbits by constricting 1 hind leg for 4 h. Local pO2 [O2 tension] on muscle surface was measured by a multiwire Pt electrode according to the method of Kessler. Untreated animals showed anoxic tissue areas after a period of 30 min of reperfusion. All these animals died in shock within 3-4 h. The glucocorticoid, prednisolone (20 mg/kg), and the proteinase inhibitor, Trasylol (20,000 KIU/kg), were administered 5 min before release of the tourniquet. These animals showed normal pO2 values during the 2-3 h observation period. Tourniquet shock was prevented and survival time prolonged by these agents. This protective effect could be correlated to the pO2 in the ischemic region.

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