Neuroloeptic effect on desipramine steady-state plasma concentratins

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Abstract
The effect of neuroleptic drugs [perphenazine, haloperidol and thiothixene] on desipramine steady-state plasma concentration was studied in 30 psychiatric patients who received similar mg/kg doses of desipramine. Of these patients, 15 also received a neuroleptic drug and had desipramine plasma levels twice that of the 15 patients who received desipramine alone. The implications of the magnitude of this difference for therapeutic response and incidence of side effects were discussed.