PROTECTION FROM HALOTHANE-INDUCED PORCINE MALIGNANT HYPERTHERMIA SYNDROME BY DROPERIDOL

  • 1 January 1980
    • journal article
    • research article
    • Vol. 30  (6) , 992-996
Abstract
Pigs (43) from 8 litters of purebred Pietrains were identified as malignant hyperthermia susceptible by halothane testing and their reaction time (measured in seconds from onset of halothane administration to onset of skeletal muscle rigidity) was recorded. One wk later, these pigs were treated with 0.02, 0.2, 0.5, 1.0 or 2.0 mg/kg of droperidol 1 h prior to a 2nd halothane test. Pigs with a post-droperidol reaction time 100.4 s (mean + 2.021 SD initial reaction time) were considered to be protected from malignant hyperthermia. Droperidol afforded some degree of protection at all doses tested. ED50 was 0.055 with 95% confidence limits of 0.017-0.183 mg/kg.

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