THE GAMMA-DELTA-BETA-GLOBIN GENE REGION IN G-GAMMA-BETA-+-HEREDITARY PERSISTENCE OF FETAL HEMOGLOBIN
- 1 January 1982
- journal article
- research article
- Vol. 59 (4) , 828-831
Abstract
Restriction endonuclease analysis of the .gamma.-.delta.-.beta.-globin gene region is reported in a mother and child heterozygous for G.gamma.-.beta.+-hereditary persistence of fetal Hb (HPFH). The affected chromosome in these persons directs the production of G.gamma.-chains and .beta.-chains but not A.gamma.-chains. DNA was digested with several restriction enzymes and was examined for .gamma., .delta., .beta. sequences by blot hybridization. Only normal digestion fragments were present. A deletion could not be detected in the entire .gamma.-.delta.-.beta.-globin gene region of the affected chromosome, indicating that in this family G.gamma.-.beta.+-HPFH is not due to a large deletion.This publication has 11 references indexed in Scilit:
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