Importance of folate-homocysteine homeostasis during early embryonic development
- 1 January 2007
- journal article
- review article
- Published by Walter de Gruyter GmbH in cclm
- Vol. 45 (12) , 1717-27
- https://doi.org/10.1515/cclm.2007.345
Abstract
Although the beneficial effects of maternal folate supplementation in the periconceptional period have been shown to prevent neural tube defects, congenital heart defects and orofacial clefts, the exact protective mechanism of folates remains unknown. Folates affect DNA synthesis, amino acid metabolism and methylation of genes, proteins and lipids via S-adenosylmethionine-mediated one-carbon transfer reactions. Our laboratory has created several mouse knock out models of folate transport using gene targeting to inactivate folate receptor 1 (Clin Chem Lab Med 2007;45:1717–27.Keywords
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