Abstract
The subcut. adm. of water to rats was found to produce a diuresis comparable to that resulting from its oral adm.; Newton and Smirk have already shown that a diuresis follows the intraven. inj. of water and the present expts. confirm their opinion as to the unimportance of the gastrointestinal tract in the mechanism of water diuresis. The subcut. injection into rats of a 5% soln. of NaCl and of certain other solns. isosmotic with it was found to delay or arrest the development of a water diuresis.

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