Proliferation in non‐hodgkin's lymphomas as determined by immunohistochemical double staining for Ki‐67

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Abstract
The authors have studied proliferation (growth fractions) in non‐Hodgkin's lymphomas (NHL) using an immunohistochemical double staining technique with the monoclonal antibody (MoAb), Ki‐67, in order to clarify the relationships between histologic type, proliferation and prognosis. The percentages of Ki‐67 positive (Ki‐67+) cells in B cell lymphomas were higher for diffuse lymphomas than for follicular lymphomas and increased in order from small to large cell types. In addition, the percentage of Ki‐67+ cells in B cell lymphomas inversely correlated with survival in months (n = 33 r = ‐0·54 p < 0·01). These results indicate that the percentage of Ki‐67+ cells in B cell lymphomas correlates with histologic type and prognosis. Although the prognosis of T cell lymphomas is considered worse than that of B cell lymphomas, the percentage of Ki‐67+ cells was lower, in general, in T cell lymphomas than in B cell lymphomas. These data indicate that proliferation in T cell lymphomas does not correlate with survival.