Comparison of Ultrasmall Superparamagnetic Iron Oxide Particles and Low Molecular Weight Contrast Agents to Detect Rejecting Transplanted Hearts With Magnetic Resonance Imaging
- 1 October 2005
- journal article
- research article
- Published by Wolters Kluwer Health in Investigative Radiology
- Vol. 40 (10) , 648-654
- https://doi.org/10.1097/01.rli.0000178431.38215.ae
Abstract
This study compared 3 different contrast agents for magnetic resonance imaging (MRI) to determine whether their rate of permeability could discriminate between acutely rejecting and nonrejecting transplanted hearts.Heterotopic heart transplantation in rats was performed and animals were divided into allogeneic and syngeneic groups. At the sixth postoperative day, MRI was performed with 2 ultrasmall superparamagnetic iron oxide particles of different sizes, unformulated NC 100150 and AMI-227, besides gadodiamide.For unformulated NC100150, the signal intensity between the groups differed at all times (P < 0.0001); for AMI-227, all times but 3 (P < 0.05). With low molecular weight gadolinium chelate, no discrimination between rejecting and nonrejecting groups could be made.Acutely rejecting and nonrejecting transplanted hearts can be discriminated from each other using the difference in permeability assessed by blood pool agents and MRI. With first pass of gadolinium chelate no discrimination could be made between rejecting and nonrejecting grafts.Keywords
This publication has 28 references indexed in Scilit:
- Twenty years of renal transplantation at Ohio State University: the results of five eras of immunosuppressionThe American Journal of Surgery, 2003
- Allograft rejection of ISHLT grade ≥3A occurring late after heart transplantation—a distinct entity?The Journal of Heart and Lung Transplantation, 2003
- In vivo detection of acute rat renal allograft rejection by MRI with USPIO particlesKidney International, 2002
- Evolution of immunosuppression and continued importance of acute rejection in renal transplantationAmerican Journal of Kidney Diseases, 2001
- Macrophage Accumulation Associated With Rat Cardiac Allograft Rejection Detected by Magnetic Resonance Imaging With Ultrasmall Superparamagnetic Iron Oxide ParticlesCirculation, 2001
- Renal Transplantation Update Series Editor: V. Ram Peddi and M. Roy First: Recent Advances in Immunosuppressive Therapy for Renal TransplantationSeminars in Dialysis, 2001
- Death after rejection with severe hemodynamic compromise in pediatric heart transplant recipients: a multi-institutional studyPublished by Elsevier ,2001
- Magnetic resonance imaging detection of rat renal transplant rejection by monitoring macrophage infiltrationKidney International, 2000
- Acute Pancreatic Transplant Rejection: Evaluation with Dynamic Contrast-enhanced MR Imaging Compared with Histopathologic AnalysisRadiology, 1999
- Functional magnetic resonance imaging of human renal allografts during the post-transplant period: Preliminary observationsMagnetic Resonance Imaging, 1997