Measurement of blood flow and vascular permeability changes in response to 12‐o‐tetradecanoyl‐phorbol‐13‐acetate and to asbestos fibers

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Abstract
The hyperemia (increased blood flow) and vascular permeability changes induced in rabbit skin by the tumor promoter 12‐O‐tetradecanoyl‐phorbol‐13‐acetate and by asbestos fibers have been quantitated. The resultant hyperemia, measured with radiolabeled microspheres, was inhibited in both cases by steroidal and nonsteroidal anti‐inflammatory drugs. Since the inflammatory responses resulting from exposure to these agents might be important for the subsequent development of neoplasms, it is proposed that such a specific and quantitative technique be used to analyze the components of these inflammatory responses in more detail.