ANTIPHLOGISTIC PROPERTY OF DESOXYCORTICOSTERONE AFTER PARTIAL HEPATECTOMY, ADRENALECTOMY, FORCE-FEEDING AND KC1 INGESTION IN THE RAT

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Abstract
Desoxycorticosterone (DOC) has been shown to be antiphlogistic in tho rat after both local and systemic administration. When given systeniically, it is, in addition, thymolytic and catabolic. It was found that these new properties of DOC are greatly augmented after removal of 70% of the liver. The efficient inactivation of the steroid by the liver may explain why high doses must be given in intact animals. The present investigations also indicate that the antiphlogistic and catabolic properties of DOC are specific and not due to stress reaction consequent to metabolic disturbances of the hormone. Actually, the effect observed was not modified by adrenalectomy, force-feeding or potassium chloride supplements. The difference in activity between DOC and cortisol appears to be mainly in degree, the former being much weaker.

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