Comparative Analysis of Tumor Cell Dissemination in Mesenteric, Central, and Peripheral Venous Blood in Patients With Colorectal Cancer

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Abstract
THE LIVER is the most common site of metastasis in patients with colorectal cancer. Despite meticulous surgical techniques and adjuvant therapy, liver metastases are the major cause of disease progression and the primary determinant of survival in patients with colorectal carcinoma.1-3 Synchronous liver metastases occur in 15% to 30% of patients at the time of primary colorectal resection, and a similar percentage of patients will develop liver metastases after colorectal resection.4 The metastatic lesions emerge from disseminated tumor cells that presumably spread from the primary tumor in the colon before or during surgery.5,6 Two major pathways of tumor cell dissemination are being discussed.

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