The microheterogeneity of rat TBG
- 27 February 1989
- journal article
- Published by Wiley in FEBS Letters
- Vol. 244 (2) , 343-346
- https://doi.org/10.1016/0014-5793(89)80559-9
Abstract
Isoelectric focusing (IEF) of native sera from immature or adult rats and of purified or partially purified rat serum thyroid hormone-binding proteins, demonstrates that rat TBG is a microheterogeneous protein. Autoradiography and radioactivity scans of the IEF plates show that it consists of at least four main isoforms, with bands at pH 4.35, 4.45, 4.5 and 4.55. This pattern is remarkably similar to that reported for human TBG. This is the first demonstration of the polymorphism of this recently discovered major binding protein of the ratKeywords
This publication has 7 references indexed in Scilit:
- Differential binding of thyroxine and triiodothyronine to acidic isoforms of thyroid hormone binding globulin in human serumBiochemistry, 1988
- A thyroxine binding globulin (TBG)-like protein in the sera of developing and adult ratsBiochemical and Biophysical Research Communications, 1987
- A simplified method for the preparation of rat thyroxine-binding prealbumin. Factors influencing its circulating levelBiochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, 1985
- Polymorphism of Human Thyroxine-Binding GlobulinJournal of Clinical Endocrinology & Metabolism, 1983
- Thyroxine-Binding Globulin: Investigation of Microheterogeneity*Journal of Clinical Endocrinology & Metabolism, 1981
- Influx of Thyroid Hormones into Rat Liver In VivoJournal of Clinical Investigation, 1980
- Studies on human thyroxine-binding globulinArchives of Biochemistry and Biophysics, 1973