SUPPRESSIVE ACTION OF CORTICOSTEROIDS ON THE SECRETION OF GROWTH HORMONE

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Abstract
SUMMARY: The effect of cortisol (5 mg./100 g. body weight administered for 10 days) on the secretion of growth hormone (GH) from the pituitary was studied in 30-day-old female rats. The results indicate that the suppressive action of cortisol on GH secretion is not due to a reduced availability of the hormone in the pituitary but to an impairment of the release mechanism(s) as shown by the lack of GH release in response to insulin hypoglycaemia and by the marked decrease of GH-releasing activity in the hypothalamus of cortisol-treated rats.

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