Gastric Lesion in Iron Deficiency Anaemia

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Abstract
Seventy-five of 100 patients with iron deficiency anemia were found to have gastritis, which was superficial in 39, slight atrophic in 21, moderate atrophic in 12 and severe atrophic in 3. The occurrence of gastritis correlated neither with age nor any of the hematologicalparameters used. With advancing degree of gastritis there was a distinct decrease in HCl secretion and uropepsin excretion. Achlorhydria was present in 28 of 98 patients. Koilonychia and papillary atrophy of the tongue occurred mainly in patients with atrophic gastritis. D-Xylose absorp-tion was impaired in 13 of 76 patients. A 2nd gastric biopsy was per-formed in 47 patients after approximately 6 mos. Fe treatment. Mor-phological improvement was noted in 6 patients and degeneration in 11, however, signs of improvement or aggravation of the mucosal state were rather slight, and in general the state of the gastric mucosa re-mained essentially unchanged. In 1 patient Fe treatment led to manifestation of polycythemia vera.

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