An Antibody Cytotoxic to Megakaryocyte Progenitor Cells in a Patient with Immune Thrombocytopenic Purpura

Publisher Website
Google Scholar
Abstract
Chronic idiopathic thrombocytopenic purpura is a syndrome characterized by bleeding due to a reduced number of platelets and normal or increased numbers of marrow megakaryocytes. The thrombocytopenia in this disorder is due to IgG antibodies that are directed against platelet antigens. The presence of these antibodies eventually results in platelet destruction by the reticuloendothelial system.1 , 2 McKenna and Pisciotta3 and McMillan and co-workers4 have provided evidence that these antibodies also react with marrow megakaryocytes. The effect of these antibodies on in vivo thrombopoiesis, however, is unknown. Harker5 and Branehög et al.6 have found that platelet turnover is increased in idiopathic thrombocytopenic . . .