The Physicochemical Properties, Plasma Enzymatic Hydrolysis, and Nasal Absorption of Acyclovir and Its 2′-Ester Prodrugs
- 1 January 1994
- journal article
- Published by Springer Nature in Pharmaceutical Research
- Vol. 11 (2) , 237-242
- https://doi.org/10.1023/a:1018903407592
Abstract
A series of 2′-( O-acyl) derivatives of 9-(2-hydoxyethoxymethyl)guanine (acyclovir) was synthesized by acid anhydride esterification. Aqueous solubilities in isotonic phosphate buffer (pH 7.4),...Keywords
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