FUNCTIONAL EVALUATION OF AUTOTRANSPLANTED LUNG IN DOG

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Abstract
Thirty-three dogs were subjected to lung autotransplantation. Systemic hepariniza-tion was used in 21 dogs, and 16 were long-term survivors. Respiratory function studies in 9 dogs showed ventilation to be unaltered but blood oxygenation significantly impaired. Pulmonary artery pressure was within normal limits in all dogs. Upon balloon occlusion of the con-tralateral pulmonary artery, pulmonary hypertension developed in 3 dogs. Respiratory studies performed on one dog that survived contra- lateral pneumonectomy for 13 days suggest that function of the auto-transplanted lung is sufficient to sustain life. Causes of death following contralateral pneumonectomy seem to lie in bronchial complications which, with further experience, possibly can be prevented.

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