Family-based association tests for quantitative traits using pooled DNA
- 3 December 2002
- journal article
- research article
- Published by Springer Nature in European Journal of Human Genetics
- Vol. 10 (12) , 870-878
- https://doi.org/10.1038/sj.ejhg.5200893
Abstract
Interest in whole-genome QTL mapping has spurred efforts to reduce the cost of studies now based primarily on individual genotyping. Pooled DNA tests are a possible solution, and understanding how measurement error affects test power could assist in study design. Here we describe pooled tests explicitly optimised for measurement error, including family-based tests robust to population stratification. Our results suggest that pooled DNA whole-genome screens may be feasible with current instruments.Keywords
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