Gene dose effect: regional mapping of human glutathione reductase on chromosome 8
- 1 January 1976
- journal article
- review article
- Published by S. Karger AG in Cytogenetic and Genome Research
- Vol. 17 (5) , 282-286
- https://doi.org/10.1159/000130723
Abstract
Quantitative glutathione reductase (GSR) assays were determined for 3 unrelated humans. The elevated activity in the red blood cells was compared with normal controls. The GSR increase is not due to a generalized gene or chromosome imbalance. The expression of 3 alleles for enzyme control in these individuals assigns GSR to chromosome 8 and is a result of a duplication of heterochromatin in the 8p21 .fwdarw. 8p23 segment.Keywords
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