DTPA-COUPLED ANTIBODIES LABELED WITH Y-90

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  • 1 January 1985
    • journal article
    • research article
    • Vol. 26  (5) , 503-509
Abstract
Yttrium-90 was described as one of the best radionuclides for [human] tumor therapy when chelated to tumor-associated antibodies. This evaluation is based on the superior properties of this radionuclide (suitable half-life, pure .beta.-ray emitter of intermediate energy, stable daughter and suitable chemical properties) and because it is available as a radionuclide generator product by decay of its 28-yr parent 90Sr. 90Y obtained from one such generator is suitable for labeling antibodies coupled with DTPA [diethylenetriaminepentaacetic acid]. The dissociation rate of [90Y]DTPA-IgG in serum at 37.degree. C is similar to that of [111In]DTPA-IgG at about 8-9%/day. Biodistribution studies of 111In- and 90Y-labeled to DTPA-coupled IgG show that the labels distribute nearly identically at 1 h postadministration, although differences in distribution are apparent at 24 h. These differences may reflect the redistribution of the labels following catabolism at the site of localization.