Tuberculostatic and Tuberculocidal Properties of Streptomycin

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Abstract
Streptomycin has been found to have a marked bactericidal as well as a bacteriostatic action upon different strains of Mycobacterium tuberculosis. The larger the inoculum and the longer the period of incubation, the greater was the amt. of streptomycin required to inhibit or to kill all the cells. In a growing culture of tubercle bacilli, the proportion of streptomycin-resistant cells decreased with age. Combinations of streptomycin and streptothricin exerted an additive rather than a synergistic effect. The principal effects of streptomycin on the morphology of tubercle bacilli were loss of acid-fastness, increase in granulation and, in highly bacteriostatic concs., shortening of the rods.
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